Vermont Oxford Network Members Collaborate on Occlusive Wrap Clinical Trial

A randomized controlled trial conducted by 39 Vermont Oxford Network members found that occlusive wrap increased mean body temperature when used with preterm infants.

The Heat Loss Prevention Trial (HeLP Trial) enrolled 817 infants born 24/0 to 27/6 weeks gestational age. Infants were assigned randomly to be wrapped or not wrapped immediately after birth. Wrapped infants had statistically significant greater baseline temperatures (36.3°C vs 35.7°C, P < .0001) and poststabilization temperatures (36.6°C vs 36.2°C, P < .001) than nonwrapped infants. Wrapped infants also had a significantly lower mean one minute Apgar score (P = .007).

There were no significant differences in the primary outcome of mortality (OR 1.0, 95% CI 0.7-1.5) although wrapped infants did have significantly lower odds of a secondary outcome, pulmonary hemorrhage (OR 0.6, 95% CI 0.3-0.9). The study was stopped early because continued enrollment would not result in the attainment of a significant difference in mortality.

The full article is available for download.

Participating centers included: Albert Einstein Medical Center, Philadelphia, PA; Aultman Hospital, Canton, OH; Avera McKennan Hospital, Sioux Falls, SD; Blank Children’s Hospital, Des Moines, IA; Brookdale Hospital Medical Center, Brooklyn, NY; Caritas St Elizabeth’s Medical Center, Boston, MA; Children’s at Cooper University Medical Center, Camden, NJ; Children’s Hospital of Wisconsin, Milwaukee, WI; CHOC Children’s Hospital, Orange, CA; Connecticut Children’s NICU at UConn Health Center, Farmington, CT; Elliot Hospital, Manchester, NH; Goryeb Children’s Hospital, Morristown, NJ; Hennepin County Medical Center, Minneapolis, MN; Henry Ford Hospital, Detroit, MI; Hospital Clinic (sede Maternitat), Barcelona, Spain; Hospital de S Joao, Porto, Portugal; Hospital de Santa Maria, Lisbon, Portugal; Hospital Universitari Joan XXIII de Tarragona, Tarragona, Spain; Jackson Memorial Hospital, Miami, FL; K.K. Women’s & Children’s Hospital, Singapore, Singapore; Lafayette General Medical Center, Layfayette, LA; The Medical Center at Columbus Regional, Columbus, GA; Mercy Health Center, Oklahoma City, OK; Mt Carmel Health Systems, Columbus, OH; National Maternity Hospital, Dublin, Ireland; Nationwide Children’s Hospital, Columbus, OH; Ochsner Clinic Foundation, New Orleans, LA; Rapides Women’s and Children’s Hospital, Alexandria, LA; Royal Maternity Service, Belfast, Ireland; St Elizabeth Regional Medical Center, Lincoln, NE; St John Hospital and Medical Center, Detroit, MI; St Luke’s Hospital, Kansas City, MO; Stamford Hospital, Stamford, CT; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Temple University Hospital, Philadelphia, PA; University Kebangsaan Malaysia, Kuala Lumpur, Malaysia; University of Iowa Children’s Hospital, Iowa City, IA; Waukesha Memorial Hospital, Waukesha, WI; and Wesley Medical Center, Wichita, KS.