Database Research and Publications

Research using the Vermont Oxford Network Databases supports quality improvement by describing relevant clinical outcomes, trends over time, and improvements in the quality, safety, and value of neonatal care. Vermont Oxford Network also undertakes research to address specific questions that seek to improve the quality of neonatal care.

Qualified investigators are invited to collaborate with Vermont Oxford Network to design and conduct research using the Vermont Oxford Network Databases. Research should contribute to quality improvement and support the mission of the Network. The confidentiality of individual patients and of data corresponding to individual hospitals will be protected. The analysis, publication, and dissemination of results from the Vermont Oxford Network Databases to the scientific community, the public, or other interested parties is conducted at the sole discretion of the Board of Directors.

For more information about collaborative research with Vermont Oxford Network, please review the Policy and Guidelines for Collaborative Research Using the Vermont Oxford Network Databases. For information on the type of data collected, please review the manuals and forms.

Related Publications

Boghossian NS, Geraci M, Edwards EM, Horbar JD. Sex differences in mortality and morbidity of infants born at less than 30 weeks’ gestation. Pediatrics. 2018 Nov 14; epub ahead of print. PubMed: 30429272

Ehret DEY, Edwards EM, Greenberg LT, Bernstein IM, Buzas JS, Soll RF, Horbar JD. Association of antenatal steroid exposure with survival among infants receiving postnatal life support at 22 to 25 weeks’ gestation. JAMA Network Open. 2018;1(6):e183235. Open access.

Edwards EM, Horbar JD. Variation in use by NICU types in the United States. Pediatrics. 2018; epub ahead of print on the Pediatrics website.

Hong CR, Fullerton BS, Han SM, Morrow KA, Edwards EM, Soll RF, Jaksic T, Horbar JD, Modi BP. Impact of disease-specific volume and hospital transfer on outcomes in gastroschisis. Journal of Pediatric Surgery. 2018; October 5; epub ahead of print. PubMed: 30343976

Mechak JT, Edwards EM, Morrow KA, Swanson JR, Vergales J. Effects of gestational age on early survivability in neonates with hypoplastic left heart syndrome. American Journal of Cardiology. 2018;122(7):1222-1230. PubMed: 30292282

Shrestha M, Scarpino SV, Edwards EM, Greenberg LT, Horbar JD. The interhospital transfer network for very low birth weight infants in the United States. EPJ Data Science. 2018;7:27. Open Access PDF.

Boghossian NS, Geraci M, Edwards EM, Horbar JD. Neonatal and fetal growth charts to identify preterm infants less than 30 weeks gestation at risk of adverse outcomes. American Journal of Obstetrics and Gynecology. 2018;219:2():195.e1-195.e14. PubMed: 29750954

Adams M, Bassler D, Bucher HU, Roth-Kleiner M, Berger TM, Braun J, Puhan MA, Edwards E, Soll R, Von Wyl V; Swiss Neonatal Network and the Vermont Oxford Network. Variability of very low birth weight infant outcome and practice in Swiss and US neonatal units. Pediatrics. 2018;141(5):e20173436. PubMed: 29654158

Boghossian NS, Geraci M, Edwards EM, Horbar JD. In-hospital outcomes in large for gestational age infants at 22 to 29 weeks’ gestation. Journal of Pediatrics. 2018;198:174-180.e13. PubMed: 29631772

Hong CR, Fullerton BS, Mercier CE, Morrow KA, Edwards EM, Ferrelli KR, Soll RF, Modi BP, Horbar JD, Jaksic T. Growth morbidity in extremely low birth weight survivors of necrotizing enterocolitis at discharge and two-year follow-up. J Pediatr Surg. 2018;53(6):1197-1202. PubMed: 29627178

Boghossian NS, Geraci M, Edwards EM, Horbar JD. Morbidity and mortality in small for gestational age infants at 22 to 29 weeks’ gestation. Pediatrics. 2018;198:174-180.e13. PubMed: 29348195

Velazco CS, Fullerton BS, Hong CR, Morrow KA, Edwards EM, Soll RF, Jaksic T, Horbar JD, Modi BP. Morbidity and mortality among “big” babies who develop necrotizing enterocolitis: A prospective cohort analysis. Journal of Pediatric Surgery. 2017 Oct 12; Epub ahead of print. PubMed: 29111080

Fullerton BS, Hong CR, Velazco CS, Mercier CE, Morrow KA, Edwards EM, Ferrelli KR, Soll RF, Modi BP, Horbar JD, Jaksic T. Severe neurodevelopmental disability and healthcare needs among survivors of medical and surgical necrotizing enterocolitis. Journal of Pediatric Surgery. 2017 Oct 12; Epub ahead of print. PubMed: 29079317

Lake ET, Staiger D, Edwards EM, Smith JG, Rogowski JA. Nursing care disparities in neonatal intensive care units. Health Services Research. 2017 Sept 14; Epub ahead of print. PubMed: 28905367

Fullerton BS, Velazco CS, Sparks EA, Morrow KA, Edwards EM, Soll RF, Modi BP, Horbar JD, Jaksic T. Contemporary outcomes of infants with gastroschisis in North America: a multicenter cohort study. Journal of Pediatrics. 2017; 188: 192-197. PubMed: 28712519

Horbar JD, Edwards EM, Greenberg LT, Morrow KA, Soll RF, Buus-Frank ME, Buzas JS. Variation in performance of neonatal intensive care units in the United States. JAMA Pediatrics. 2017;171(3):e164396. PubMed: 28068438

McBride CA, Bernstein IM, Badger GJ, Soll RF. Maternal hypertension and mortality in small for gestational age 22- to 29-week infants. Reproductive Science. 2017 Jan 1:1933719117711260. Epub ahead of print. PubMed: 28578635

Boghossian NS, Geraci M, Edwards EM, Morrow KA, Horbar JD. Anthropometric charts for infants born between 22 and 29 weeks’ gestation. Pediatrics. 2016; 138(6): e20161641. PubMed: 27940694

Fullerton BS, Sparks EA, Morrow KA, Edwards EM, Soll RF, Jaksic T, Horbar JD, Modi BP. Hospital transfers and patterns of mortality in very low birth weight neonates with surgical necrotizing enterocolitis. Journal of Pediatric Surgery. 2016 Jun;51(6):932-5. PubMed: 27230800

McBride CA, Bernstein IM, Badger GJ, Horbar JD, Soll RF. The effect of maternal hypertension on mortality in infants 22, 29 weeks gestation. Pregnancy and Hypertension. 2015; 5(4): 362-366. PubMed: 26597755

Rochow N, Landau-Crangle E, Lee S, Schunemann H, Fusch C. Quality indicators but not admission volumes of neonatal intensive care units are effective in reducing mortality rates of preterm infants. PLoS One. 2016; 11(8): e0161030. PubMed: 27508499

Hallowell SG, Rogowski JA, Spatz DL, Hanlon AL, Kenny M, Lake ET. Factors associated with infant feeding of human milk at discharge from neonatal intensive care: Cross-sectional analysis of nurse survey and infant outcomes data. International Journal of Nursing Studies. 2015 Oct 9. PubMed: 26518107

Rogowski JA, Staiger DO, Patrick TE, Horbar JD, Kenny MJ, Lake ET. Nurse staffing in neonatal intensive care units in the United States. Research in Nursing and Health. 2015; 38(5): 333-41. PubMed: 26291315

Horbar JD, Ehrenkranz RA, Badger GJ, Edwards EM, Morrow KA, Soll RF, Buzas JS, Bertino E, Gagliardi L, Bellu R. Weight growth velocity and postnatal growth failure in infants 501 to 1500 grams: 2000-2013. Pediatrics. 2015;136(1): e84-e92. PubMed: 26101360

Ioannidis JP, Horbar JD, Ovelman CM, Brosseau Y, Thorlund K, Buus-Frank ME, Mills EJ, Soll RF. Completeness of main outcomes across randomized trials in entire discipline: survey of chronic lung disease outcomes in preterm infants. BMJ. 2015;350:h72. PubMed: 25623087

Fisher JG, Bairdain S, Sparks EA, Khan FA, Archer JM, Kenny M, Edwards EM, Soll RF, Modi BP, Yeager S, Horbar JD, Jaksic T. Serious congenital heart disease and necrotizing enterocolitis in very low birth weight neonates. Journal of the American College of Surgeons. 2015;220(6): 1018-1026.e14. PubMed: 25868405

Sparks EA, Gutierrez IM, Fisher JG, Khan FA, Kang KH, Morrow KA, Soll RF, Edwards EM, Horbar JD, Jaksic T, Modi BP. Patterns of surgical practice in very low birth weight neonates born in the United States: a Vermont Oxford Network analysis. Journal of Pediatric Surgery. 2014;49(12): 1821-1824.e8. PubMed: 25487492

Reilly MC, Vohra S, Rac VE, Dunn M, Ferrelli K, Kiss A, Vincer M, Wimmer J, Zayack D, Soll RF; Vermont Oxford Network Heat Loss Prevention (HeLP) Trial Study Group. Randomized trial of occlusive wrap for heat loss prevention in preterm infants. Journal of Pediatrics. 2015; 166(2): 262-268. PubMed: 25449224

Sarkar IN, Chen ES, Rosenau PT, Storer MB, Anderson B, Horbar JD. Using Arden Syntax to identify registry-eligible very low birth weight neonates from the Electronic Health Record. AMIA Annual Symposium Proceedings. 2014;2014: 1028-36. PubMed: 25954412

Lake ET, Staiger D, Horbar J, Kenny MJ, Patrick T, Rogowski JA. Disparities in perinatal quality outcomes for very low birth weight infants in neonatal intensive care. Health Services Research. 2015;50(2): 374-397. PubMed: 25250882

Fisher JG, Jones BA, Gutierrez IM, Hull MA, Kang KH, Kenny M, Zurakowski D, Modi BP, Horbar JD, Jaksic T. Mortality associated with laparotomy-confirmed neonatal spontaneous intestinal perforation: A prospective 5-year multicenter analysis. Journal of Pediatric Surgery. 2014;49(8): 1215-1219. PubMed: 25092079

Hallowell SG, Spatz DL, Hanlon AL, Rogowski JA, Lake ET. Characteristics of the NICU work environment associated with breastfeeding support. Advances in Neonatal Care. 2014;14(4):290-300. PubMed: 25075926

Turcotte LM, Georgieff MK, Ross JA, Feusner JH, Tomlinson GE, Malogolowkin MH, Krailo MD, Miller N, Fonstad R, Spector LG. Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: A report from the Children’s Oncology Group. Pediatric Blood Cancer. 2014;61(11): 2018-23. PubMed: 25044669

Barnette AR, Horbar JD, Soll RF, Pfister RH, Nelson KB, Kenny MJ, Raju TN, Bingham PM, Inder TE. Neuroimaging in the evaluation of the newborn brain. Pediatrics. 2014;133: e1508-e1517. PubMed: 24864165

Hull MA, Fisher JG, Gutierrez IM, Jones BA, Kang KH, Kenny M, Zurakowski D, Modi BP, Horbar JD, Jaksic T. Mortality and management of surgical necrotizing enterocolitis in very low birth weight neonates: a prospective cohort study. Journal of the American College of Surgeons. 2014;218(6): 1148-55. PubMed: 24468227

LeVan JM, Wyckoff MH, Ahn C, Heyne R, Sanchez PJ, Chalak L, Jaleel MA, Burchfield PJ, Christie L, Soll R, Badger GJ, Brion LP. Change in care among nonenrolled patients during and after a randomized trial. Pediatrics. 2013;132(4): e960-970. PubMed: 24043277

Vohra S, Reilly M, Rac VE, Bhaloo Z, Zayack D, Wimmer J, Vincer M, Ferrelli K, Kiss A, Soll R, Dunn M. Study protocol for multicentre randomized controlled trial of HeLP (Heat Loss Prevention) in the delivery room. Contemporary Clinical Trials. 2013;36(1): 54-60. PubMed: 23770234

Soll RF, Edwards EM, Badger GJ, Kenny MJ, Morrow KA, Buzas JS, Horbar JD. Obstetric and neonatal care practices for infants 501 to 1500 g from 2000 to 2009. Pediatrics. 2013;132(2): 222-228. PubMed: 23858426

Rogowski JA, Staiger D, Patrick T, Horbar J, Kenny M, Lake ET. Nurse staffing and NICU infection rates. JAMA Pediatrics. 2013;167(5): 444-450. PubMed: 23549661

Nelson KB, Bingham P, Edwards EM, Horbar JD, Kenny MJ, Inder T, Pfister RH, Raju T, Soll RF. Antecedents of neonatal encephalopathy in the Vermont Oxford Network Neonatal Encephalopathy Registry. Pediatrics. 2012; 130(5): 878-886. PubMed: 23071210

Pfister RH, Bingham P, Edwards EM, Horbar JD, Kenny MJ, Inder T, Nelson KB, Raju T, Soll RF. The Vermont Oxford Neonatal Encephalopathy Registry: rationale, methods, and initial results. BMC Pediatrics. 2012; 12(1): 84. PubMed: 22726296

Horbar, JD, Carpenter JH, Badger GJ, Kenny MJ, Soll RF, Morrow KA, Buzas JS. Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009. Pediatrics. 2012;129(6): 1019-1026. PubMed: 22614775

Al-Hosni M, Duenas M, Hawk M, Stewart LA, Borghese RA, Cahoon M, Atwood L, Howard D, Ferrelli K, Soll R. Probiotics-supplemented feeding in extremely low-birth-weight infants. Journal of Perinatology. 2012;32(4): 253-259. PubMed: 21546942

Boghossian NS, Horbar JD, Murray JC, Carpenter JH; Vermont Oxford Network. Anthropometric charts for infants with trisomies 21, 18, or 13 born between 22 weeks gestation and term: The VON charts. American Journal of Medical Genetics Part A. 2012;158A(2): 322-332. PubMed: 22246859

Boghossian NS, Horbar JD, Carpenter JH, Murray JC, Bell EF, Vermont Oxford Network. Major chromosomal anomalies among very low birth weight infants in the Vermont Oxford Network. Journal of Pediatrics. 2012;160(5): 774-780.e11. PubMed: 22177989

Eppstein MJ, Horbar JD, Buzas JS, Kauffman SA. Searching the clinical fitness landscape. PLOS One. 2012;7(11): e49901. PubMed: 23166791

Lake ET, Staiger D, Horbar J, Cheung R, Kenny M, Patrick T, Rogowski J. Association between hospital recognition for nursing excellence and outcomes of very low-birth-weight infants. JAMA. 2012;307(16): 1709-1716. PubMed: 22535856

Archer JM, Yeager SB, Kenny MJ, Soll RF, Horbar JD. Distribution of and mortality from serious congenital heart disease in very low birth weight infants. Pediatrics. 2011;127(2): 293-299. PubMed: 21220403

Dunn MS, Kaempf J, de Klerk A, de Klerk R, Reilly M, Howard D, Ferrelli K, O’Conor J, Soll RF; Vermont Oxford Network DRM Study Group. Randomized trial comparing 3 approaches to the initial respiratory management of preterm neonates. Pediatrics. 2011;128(5): e1069-e1076. PubMed: 22025591

Mercier CE, Dunn MS, Ferrelli KR, Howard DB, Soll RF; Vermont Oxford Network ELBW Infant Follow-Up Study Group. Neurodevelopmental outcome of extremely low birth weight infants from the Vermont Oxford Network: 1998-2003. Neonatology. 2010;97(4): 329-338. PubMed: 19940516

Horbar JD, Soll RF, Edwards WH. The Vermont Oxford Network: a community of practice. Clinics in Perinatology. 2010;37(1): 29-47. PubMed: 20363446

Sarkar S, Barks JD. Systemic complications and hypothermia. Seminars in Fetal and Neonatal Medicine. 2010;15(5): 270-275. PubMed: 20227357

Fitzgibbons SC, Ching Y, Yu D, Carpenter J, Kenny M, Weldon C, Lillehei C, Valim C, Horbar JD, Jaksic T. Mortality of necrotizing enterocolitis expressed by birth weight categories. Journal of Pediatric Surgery.2009;44(6): 1072-1075; discussion 1075-1076. PubMed: 19524719

Zupancic JA, Richardson DK, Horbar JD, Carpenter JH, Lee SK, Escobar GJ; Vermont Oxford Network SNAP Pilot Project Participants. Revalidation of the score for neonatal acute physiology in the Vermont Oxford Network. Pediatrics. 2007;119(1): e156-e163. PubMed: 17158947

Walsh MC, Yao Q, Horbar JD, Carpenter JH, Lee S, Ohlsson A. Changes in the use of postnatal steroids in three large neonatal networks. Pediatrics. 2006;118(5): e1328-e1335. PubMed: 17079534

Morales LS, Staiger DO, Horbar JD, Carpenter J, Kenny M, Geppert J, Rogowski J. Mortality among very low birthweight infants in hospitals serving minority population. American Journal of Public Health. 2005;95(12): 2206-2212. PubMed: 16304133

Edwards WH, Conner JM, Soll RF; Vermont Oxford Network Neonatal Skin Care Study Group. The effect of prophylactic ointment therapy on nosocomial sepsis rates and skin integrity in infants with birth weights of 501 to 1000 g. Pediatrics. 2004;113(5): 1195-1203. PubMed: 15121929

Horbar JD, Carpenter JH, Buzas J, Soll RF, Suresh G, Bracken MB, Leviton LC, Plsek PE, Sinclair JC. Collaborative quality improvement to promote evidence-based surfactant for preterm infants: A cluster randomized trial. BMJ. 2004;329(7473): 1004-1007. PubMed: 15514344

Horbar JD, Carpenter JH, Buzas J, Soll RF, Suresh G, Bracken MB, Leviton LC, Plsek PE, Sinclair JC for the Members of the Vermont Oxford Network. Timing of initial surfactant treatment for infants 23 to 29 weeks’ gestation: Is routine practice evidence-based? Pediatrics. 2004;113(6): 1593-1602. PubMed: 15173479

Lucey JF, Rowan CA, Shiono P, Wilkinson AR, Kilpatrick S, Payne NR, Horbar JD, Carpenter J, Rogowski J, Soll RF. Fetal infants: The fate of 4172 infants with birth weights of 401 to 500 grams-The Vermont Oxford Network experience (1996-2000). Pediatrics. 2004;113(6): 1559-1566. PubMed: 15173474

Rogowski JA, Staiger DO, Horbar JD. Variations in the quality of care for very low birth weight infants: Implications for policy. Health Affairs. 2004;23(5): 88-97. PubMed: 15371373

Rogowski JA, Horbar JD, Staiger DO, Kenny M, Carpenter J, Geppert J. Indirect vs direct hospital quality indicators for very low birth weight infants. JAMA. 2004;291(2): 202-209. PubMed: 14722146

Girish SV, Leaf AA. International benchmarking in neonatal intensive care: The Vermont-Oxford Network. Clinical Governance Bulletin. 2003;(3): 8-10.

Horbar JD, Badger GJ, Carpenter JH, Fanaroff AA, Kilpatrick S, LaCorte M, Phibbs R, Soll RF; Vermont Oxford Network. Trends in mortality and morbidity for very low birth weight infants, 1991-1999. Pediatrics. 2002;110(1): 143-151. PubMed: 12093960

Suresh GK, Horbar JD, Kenny M, Carpenter JH for the Vermont Oxford Network. Major birth defects in very low birth weight infants in the Vermont Oxford Network. Journal of Pediatrics. 2001;139(3): 366-373. PubMed: 11562615

Vermont Oxford Network Steroid Study Group. Early postnatal dexamethasone therapy for the prevention of chronic lung disease. Pediatrics. 2001;108(3): 741-748. PubMed: 11533345

Bernstein IM, Horbar JD, Badger G, Ohlsson A, Golan A for the Vermont Oxford Network. Morbidity and mortality in growth restricted very low birth weight newborns. American Journal of Obstetrics and Gynecology. 2000;182(1): 198-206. PubMed: 10649179

Finer NN, Horbar JD, Carpenter JH; Vermont Oxford Network. Cardiopulmonary resuscitation in the very low birth weight infant: The Vermont Oxford Network experience. Pediatrics. 1999;104(3): 428-434. PubMed: 10469765

Horbar JD; Vermont Oxford Network. Increasing use of antenatal corticosteroid therapy between 1990 and 1993 in the Vermont Oxford Network. Journal of Perinatology. 1997;17(4): 309-313. PubMed: 9280098

Horbar JD, Badger GJ, Lewit EM, Rogowski J, Shiono P; Vermont Oxford Network. Hospital and patient characteristics associated with variation in 28-day mortality rates for very low birth weight infants. Pediatrics. 1997;99(2): 149-156. PubMed: 9024438

Vermont-Oxford Neonatal Network. A multicenter, randomized trial comparing synthetic surfactant with modified bovine surfactant extract in the treatment of neonatal respiratory distress syndrome. Pediatrics. 1996; 97(1): 1-6. PubMed: 8545199

Horbar JD; Investigators of the Vermont-Oxford Neonatal Network. Antenatal corticosteroid treatment and neonatal outcomes for infants 501 to 1500 grams in the Vermont-Oxford Neonatal Network. American Journal of Obstetrics and Gynecology. 1995;173(1): 275-281. PubMed: 7631703

Horbar JD, Leahy K; Investigators of the Vermont-Oxford Trials Network. An assessment of data quality in the Vermont-Oxford Trials Network Database. Controlled Clinical Trials. 1995;16: 51-61. PubMed: 7743789

Wright LL, Horbar JD, Gunkel H, Verter J, Younes N, Andrews E, Long W. Evidence from multicenter networks on the current use of antenatal corticosteroids in very low birth weight infants. American Journal of Obstetrics and Gynecology. 1995:173(1): 263-269. PubMed: 7631701

The Investigators of the Vermont-Oxford Trials Network Database Project. The Vermont-Oxford Trials Network: Very low birthweight outcomes for 1990. Pediatrics. 1993;91(3): 540-545. PubMed: 8441556

Horbar JD. Birthweight-adjusted mortality rates for assessing the effectiveness of neonatal intensive care. Medical Decision Making. 1992;12(4): 259-264. PubMed: 1484474

Horbar JD, McAuliffe TL, Adler SM, Albersheim S, Cassady G, Edwards W, Jones R, Kattwinkel J, Kraybill EN, Krishnan V, Raschko P, Wilkinson AR. Variability in 28-day outcomes for very low birth weight infants: an analysis of 11 neonatal intensive care units. Pediatrics. 1988;82(4): 554-559. PubMed: 3273485

Return to top